FOS and type 1 diabetes mellitus: Figure 4B illustrates paracellular leaks (arrowhead) and leaks through goblet cells (arrow; star indicates goblet cell). The proportion of leaks via goblet cells was significantly higher in STZ mice than in the controls (70.93 ± 5.33% vs. 51.58 ± 4.95%, p < 0.05; Figure 4C), whereas paracellular leaks were significantly lower (29.39 ± 5.52% vs. 48.42 ± 4.95%, p < 0.05; Figure 4D). FOS treatment did not significantly affect the distribution of leak pathways (Figure 4C,D), suggesting that goblet cells are the predominant leak pathway in STZ-induced type 1 diabetic mice.