It is well known that the two major signaling pathways (ERK and p38 MAPK and the PI3K/AKT) are constitutively activated in colorectal cancers due to genetic alterations [104] and are regulated by receptor tyrosine kinases (RTKs) and heterotrimeric G-protein-coupled receptors (GPCR). This evidence concerns the gene NTRK1 and colorectal cancer.