COXFA4L2 and malignant colon neoplasm: Overexpression of NDUFA4L2, which is also upregulated in HCT116 oxpl-R cells (log2 fold change = 2.14), is reported to be linked with poor prognosis in colon cancer [61] and serves as a prognostic biomarker for most cancers, including colon cancer [62].