In comparison to the equivalent normal tissues, TIMP3 was significantly reduced in various cancer types, including lung adenocarcinoma (LUAD), kidney chromophobe (KICH), lung squamous cell carcinoma (LUSC), colorectal cancer (CRC), and uterine carcinosarcoma (UCS) tissues (Figure 1B). Here, TIMP3 is linked to chromophobe renal cell carcinoma.