Pathogenic C. acnes target sebocytes, and the highly enriched C. acnes in the sebaceous glands/sebocytes stimulate the release of inflammatory factors to promote acne progression, wherein C. acnes can induce sebocyte lipogenic activity via the corticotropin-releasing hormone/corticotropin-releasing hormone receiver and the insulin-like growth factor/insulin-like growth factor receiver system [32,80]. This evidence concerns the gene CRH and acne.