In HNSCC, Gal-1 expression correlates with the presence of αSMA-positive CAFs and is also associated with the expression of several molecules, such as MAP3K2 (Mitogen-Activated Protein Kinase Kinase Kinase 2), TRIM23, PTPLAD1, FUSIP1 (Fused in Sarcoma protein), SLC25A40 (Solute Carrier Family 25 Member 40), Spindlin 1 (SPIN1), and others [63]. The gene discussed is GAL; the disease is head and neck squamous cell carcinoma.