AKT1 and acute respiratory distress syndrome: In lipopolysaccharide (LPS)-induced ALI, hUCMSC-EVs alleviate inflammation by inhibiting macrophage pyroptosis, which may be achieved by transferring pyroptosis-targeting miRNAs and immunomodulatory proteins through hUCMSC-EVs [32], while ADMSC-EVs mainly protect pulmonary endothelial cells from acute injury through the PI3K/Akt pathway [33].