They can also significantly reduce the expression of pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α, interferon-γ (IFN-γ), and interleukin-10 (IL-10), indicating that ADMSC-EVs have beneficial effects in influenza A virus (H1N1)-induced acute lung injury (ALI) [31]. This evidence concerns the gene TNF and acute respiratory distress syndrome.