Pseudo-hyperaldosteronism includes MR-dependent forms (apparent mineralocorticoid excess, licorice ingestion, severe forms of Cushing’s Syndrome) and the MR-independent Liddle syndrome (ENaC gain-of-function), which is unresponsive to mineralocorticoid receptor antagonists (MRAs) but corrected by ENaC blockade (Table 2). The gene discussed is NR3C2; the disease is Increased circulating aldosterone concentration.