Similar observations were made regarding other tumors, in which higher levels of Claspin expression were observed in tumors of higher grades than in lower-grade tumors or normal tissue samples (e.g., urothelium, prostate, renal cell carcinoma) [95,96,101], which is consistent with the presence of a higher number of proliferating cells in carcinoma than in normal tissues. Here, CLSPN is linked to hereditary clear cell renal cell carcinoma.