PROM1 and cancer: For instance, Jia and colleagues [98], who classified Claspin as an oncogene, found a positive association of Claspin expression with immune cell infiltration, namely, CD8+ T cells, macrophages, neutrophils, B cells, and dendritic cells, and with angiogenesis-associated factors, such as EGFR, and CD44 and CD133, two cancer stem cell markers [98].