The proteomic approach also led to some interesting suggestions with potential medical relevance, such as links between PEX3, which is associated with the Zellweger syndrome, and the biogenesis of various collagens, as well as between a subclass of Congenital Disorders of Glycosylation (CDGs) and the role of TRAP in the biogenesis of many glycoproteins [7,149,151]. This evidence concerns the gene PMM2 and Zellweger syndrome.