SEC61A1 and hereditary disease: This further milestone is of particular interest as it also enables the functional characterization of mutated forms of the Sec61 complex and components such as Sec62, Sec63, and TRAP (Figure 3), which are associated with human hereditary diseases, such as Sec61 channelopathies [46,47,143,144,145,146,147,148,149,150,151,152].