Among the TRPV1 activators, we selected capsaicin, a natural compound derived from chili peppers, based on the following: (1) its status as a well-characterized TRPV1 agonist [49,50,51,52], (2) its physiological relevance as a nutraceutical, and (3) its reported anti-cancer effects in several models, including OS [53,54,55]. The gene discussed is TRPV1; the disease is cancer.