Additionally, TRPV1 inhibition restored the nuclear-to-cytoplasmic (N/C) ratio—a surrogate marker for tumor aggressiveness—by approximately 70% after stretch in U-2 OS cells (p < 0.01) and fully reverted it to baseline levels in SAOS-2 cells (p < 0.05; Figure 1B). Here, TRPV1 is linked to neoplasm.