To elucidate changes in circulating metabolite levels, we quantified the gene expression of primary molecules involved in regulating FA metabolism (PGC-1α, PPARα, and ERRα) and glucose uptake (GLUT-1 and GLUT-4) during ischemia and immediately after reperfusion in the infarcted, adjacent, and remote regions. The gene discussed is PPARGC1A; the disease is ischemia.