Myelin Basic Protein (MBP) antigens, linear and cyclic, known to contain many arginines, have been extensively studied by us to investigate cytokine secretions in peripheral blood mononuclear cells (PBMC) in multiple sclerosis patients [220] and structural requirements for the binding of MBP peptides to the Major Histocompatibility Complex Class II molecule (MHC II) [221]. The gene discussed is MBP; the disease is multiple sclerosis.