The Ph translocation leads to the constitutive activation of the ABL1 tyrosine kinase, which plays a central role in the pathogenesis of several hematologic malignancies, including CML, B-cell acute lymphoblastic leukemia (B-ALL), mixed-phenotype acute leukemia and, in rare cases, AML [4,5,6,7]. This evidence concerns the gene ABL1 and acute lymphoblastic leukemia.