The Ph translocation leads to the constitutive activation of the ABL1 tyrosine kinase, which plays a central role in the pathogenesis of several hematologic malignancies, including CML, B-cell acute lymphoblastic leukemia (B-ALL), mixed-phenotype acute leukemia and, in rare cases, AML [4,5,6,7]. Here, ABL1 is linked to acute leukemia.