PDCD6 and cancer: TRA2β activates the glycogen synthase kinase 3-β-catenin (GSK3/β-catenin) pathway leading to the destabilization of β-catenin, a protein associated with cancer progression signaling pathways, increasing the splicing of proliferation and differentiation genes such as Meis homeobox 1 (MEIS1) and programmed cell death 6 (PDCD6) [39].