JUN and diabetes mellitus: Among the targets of miR-1285-3p are YAP/YAP1 (involved in the HIPPO signaling pathway related to cellular proliferation and migration in T3M4 and SU.8686 cell lines), Jun (a proto-oncogene product that activates the AP1 protein responsible for proliferation, cellular differentiation, apoptosis, and control of oncogenic transformation), and p53 (which participates in metabolism and diabetes development by promoting insulin resistance through regulation of the GLUT-1 receptor).