Markers such as the overexpression of the L1 cell adhesion molecule (L1CAM), mutations in the β-catenin gene (CTNNB1), absence of estrogen and progesterone receptors, and amplification of the long arm of chromosome 1 (1q) are considered potentially useful for a more accurate differentiation and stratification of NSMP cancers [18]. The gene discussed is L1CAM; the disease is cancer.