Type 1 IFNs are critical for the generation of IL-10 producing effector CD8+T cells during infections by promoting the production of IL-27 from local APCs, along with directly targeting effector CD8+T cells, which enhance the Blimp-1 (B-lymphocyte-induced maturation protein-1) and IRF4 TF expression required for IL-10 production [448]. This evidence concerns the gene CD8A and infection.