CD8A and cancer: These CD8+CTLs with Th2 function are also reported in the immunosuppressive TME of different cancers, such as cervical and urothelial bladder cancers, due to the loss of cytotoxic action and acquisition of Th2 characteristics to support immunosuppressive TME due to the loss of their antitumor cytotoxic action (Figure 3) [211,216,217,218,219].