GZMB and systemic lupus erythematosus: Type 1 IFNs increase the cytotoxic function of T cells by upregulating IFN regulatory factor 7 (IRF7) expression, which is responsible for GzmB production in AID, such as autoimmune kidney disease in mice and systemic lupus erythematosus (SLE) in humans and associated glomerulonephritis [196].