For example, IL-22 increases innate immunity against HIV infection via inducing the production of acute phase proteins, like acute phase serum amyloid A (A-SAA), which downregulates chemokine receptor 5 (CCR5, a HIV-1 entry receptor) expression by inducing its phosphorylation on APCs, such as DCs, to avoid their infection with the virus [259,260]. Here, CCR5 is linked to infection.