IFNG and infection: Moreover, IFN-γ-deficient children, along with an increased predisposition to mycobacterial infections and recurrent infections, exhibit defective neutrophil chemotaxis due to its direct effect on their different chemokine receptors, such as CCR1, CCR3, CCR6, and CXCR4; defective MHC-II expression; pro-inflammatory cytokines (TNF-α and IL-1β upregulation and IL-18 downregulation); reactive oxygen species (ROS) production; and decreased NK cell activity, indicating a critical role of IFN-γ in innate immunity and inflammatory process regulation [428].