KLF2 and neoplasm: Interestingly, the expression of Kruppel-like factor 2 (KLF2) TF prevents the generation of exhausted CD8+CTLs, maintaining their lineage fidelity and polyfunctional tumor-specific progenitor traits by suppressing thymocyte selection-related HMG (high mobility group) box protein (TOX) TF, responsible for exhausted CD8+CTL generation, and upregulating T-bet TF expression [168].