A different subset of CD8+CTLs has been identified in patients with leprosy (caused by Mycobacterium leprae), expressing natural killer (NK) cell receptors NKG2C (NKG2-C type II integral membrane protein) and NK Group 2 family of receptor A (NKG2A or CD159a, which form heterodimers with CD94 and trigger stimulatory action upon activation signaling) along with granzymes (Gzms), granulysin (not expressed in mice), and perforin and kill macrophages infected with M. leprae [95]. The gene discussed is KLRC2; the disease is leprosy.