PAX5 and familial pancreatic carcinoma: Furthermore, our study showed that the increased expression of CCL5, EBF1, and PAX5 may result from reduced expression of hsa-miR-34a-5p (Figure 6); however, in contrast, administration of miR-34a-3p and -5p in a circular dumbbell RNA form has been shown to induce CCL5 expression in pancreatic cancer cells and suppress angiogenesis in HUVECs and zebrafish embryos [72].