TGFB1 and triple-A syndrome: This analysis was performed for gene and protein signatures identified as upregulated in the LEAD vs. AAA comparison (TGFB1, VEGFA, and VEGFB), upregulated in the LEAD vs. VV comparison (VEGFB, VEGF-C), downregulated in the LEAD vs. VV comparison (CCL5, ANGPT-1, TGF-alpha, VEGF-A), and downregulated in the AAA vs. VV comparison (TGF-alpha, TGF-beta 1).