ANGPT1 and triple-A syndrome: The plasma concentrations of six key regulators of angiogenesis (ANGPT-1, ANGPT-2, TGF-alpha, TGF-beta 1, VEGF-A, and VEGF-C) were compared among the LEAD, AAA, and VV groups, employing the same comparative framework used for the gene expression analysis (LEAD vs. AAA, LEAD vs. VV, and AAA vs. VV).