EGFR and colorectal cancer: Furthermore, notable genetic alterations to the BRAF/MEK/PI3K signature resulted in a dysregulated VEGF signaling pathway, EGFR signaling pathway involving BRAF 12% and PIK3CA 21% alterations together with other genes causing cell proliferation, migration, growth, and survival signaling pathways, such as the RAS pathway, in colorectal cancer (Figure 7E–G).