Furthermore, notable genetic alterations to the BRAF/MEK/PI3K signature resulted in a dysregulated VEGF signaling pathway, EGFR signaling pathway involving BRAF 12% and PIK3CA 21% alterations together with other genes causing cell proliferation, migration, growth, and survival signaling pathways, such as the RAS pathway, in colorectal cancer (Figure 7E–G). This evidence concerns the gene PIK3CA and colorectal cancer.