The hypothesis obtained from the bioinformatics and experimental analysis of this study gives more clarity for future studies, having observed the mutational sequence, cancer upregulation, cancer hallmark, proliferative signals, relative mRNA levels of these genes in HCT116/RKO cells, and tumor growth of the BRAF/MEK/PI3K signature in colorectal cancer. The gene discussed is MAP2K7; the disease is neoplasm.