Although mutant models had lower neutrophil, monocyte, NKT, and CD8_naive levels, there was a stronger positive correlation between TME and BRAF/MEK/PI3K signaling, with high expression of macrophages, NK cells, DCs, memory cells, infiltration score, and Tregs in CRC mutants compared to wild-type. This evidence concerns the gene BRAF and colorectal carcinoma.