Increased SHCBP1 expression is detected in a wide range of tumors, including breast cancer, non-small-cell lung carcinoma (NSCLC), gastric adenocarcinoma, hepatocellular carcinoma (HCC), leukemias, gliomas, and cutaneous cancers [13,14,15,16,17,18,19]. The gene discussed is SHCBP1; the disease is hepatocellular carcinoma.