SMAD4 and neoplasm: As can be seen in Figure 8, heatmap and volcano plot analyses showed a relatively modest increase in gene expression for YY1 and several oncogenes, such as USP21, mTOR, AKT1 G6PD, and HDAC2, and the same for some negatively regulated tumor suppressors, including RB2, KDM6A, GATA3, SMAD4, and TBX3.