BRG1 (also known as SMARC4), a core subunit of the SWI/SNF complex, is overexpressed in adult B-ALL and promotes leukemogenesis by repressing PPP2R1A, activating PI3K/AKT signaling, and upregulating c-Myc. This evidence concerns the gene SMARCA4 and precursor B-cell acute lymphoblastic leukemia.