Similarly, Brady et al. highlighted that DUX4r pediatric B-ALL exhibited the highest prevalence of epigenetic alterations (66%), predominantly affecting KMT2D, TBL1XR1, and SETD2, while hyperdiploid and near-haploid subtypes frequently harbored CREBBP mutations [19]. This evidence concerns the gene CREBBP and precursor B-cell acute lymphoblastic leukemia.