Xiao et al. demonstrated that in Ph-negative adult B-ALL, mutations in epigenetic regulators increased from 16.7% at diagnosis to 46.4% at relapse post-transplant, with SETD2, CREBBP, KDM6A, and NR3C1 being the most affected [23]. This evidence concerns the gene CREBBP and precursor B-cell acute lymphoblastic leukemia.