This might resemble an intriguing case of a tumor containing two genetically and anatomically distinct cell populations, one of which is carrying a KRAS point mutation in the Q61 hotspot and secreting cftDNA into bile, while the other has KRAS CNG and point mutations in the KRAS G12/G13 hotspots and is secreting cftDNA into blood. The gene discussed is KRAS; the disease is neoplasm.