CYP4V2 and diabetes mellitus: Additionally, Merscher-Gomez et al. demonstrated, both in vivo (human podocyte cells exposed to serum from diabetics with albuminuria) and in vivo (BTBT ob/ob murine model of diabetes, recognized as a robust model of progressive diabetic nephropathy), that the induction of cholesterol efflux mediated by HP-β-CD preserves podocyte integrity and reduces markers of kidney damage.