The most prevalent pathogenic variant found in the PCa patient cohort was SPOP c.398T>G (Polyphen-2 score = 1; Grantham score = 155; n = 3; 4.68%), followed by TP53 c.578A>C (Polyphen-2 score = 1; Grantham score = 77; n = 2; 3.1%) and EIF4E c.144_145delTA (frameshift deletion; Polyphen-2 and Grantham score; n = 2; 3.1%). This evidence concerns the gene SPOP and posterior cortical atrophy.