INS and type 2 diabetes mellitus: It has been reported that COVID-19, in patients with well-controlled T2DM, impacts at the metabolic level, since it has been observed that a mild or moderate SARS-CoV-2 infection decreases metabolic parameters, such as total cholesterol, triglycerides, body mass index and insulin-related indices, which could be related to the sustained effects of the acute phase of the infection [227].