The NLRP3 inflammasome has been observed to be increased in serum and saliva in patients with periodontitis, playing an important role in the COVID-19 cytokine storm [183], and has been shown to aggregate in the lungs, resulting in fatal pneumonia [184], thus providing the potential molecular link between viral infection and cytokine release syndrome [185]. This evidence concerns the gene NLRP3 and periodontitis.