The overexpression of some non-canonical isoforms, and their association with tumoral development, poor prognosis, and drug resistance (HK2/HK3/HKDC1/ALDA/GAPDHS/PGK2) (Supplementary Table S2) in AUD patients seems relevant, especially knowing that alcohol is involved in the development of various types of cancer, and the aberrant regulation of some hexokinases can contribute to the development and progression of pathologies [53]. The gene discussed is GAPDHS; the disease is cancer.