Furthermore, Prx5-silenced UUO (unilateral ureteral obstruction) mice and 209/MDCT cells expressing C48S mutant Prx5 reveal that loss of Prx5’s peroxidatic cysteine biases TGF-β responses toward the EGFR/STAT3 axis, while only wild-type Prx5 suppresses EGFR-Y1068 and Stat3-Y705 phosphorylation and limits renal fibrosis (Figure 4) [106]. This evidence concerns the gene STAT3 and renal fibrosis.