Also, in human IMR-32 neuroblastoma cells, eosinophil peroxidase binds to cell-surface glycosaminoglycans to trigger ERK1/2 phosphorylation and NF-κB activation, which drives choline acetyltransferase and VAChT (vesicular acetylcholine transporter) expression to promote cholinergic plasticity [141]. The gene discussed is SLC18A3; the disease is neuroblastoma.