BCL2 and colorectal carcinoma: In SW480 CRC cells treated with the pro-oxidant β-lapachone, Liu et al. [87] showed that overexpressing Prx5 scavenged ROS, increased inhibitory the Ser9-GSK-3β, and stabilized β-catenin, thereby protecting cells from apoptosis and tipping Bcl-2 (B-cell lymphoma 2) family proteins toward survival.