Peng et al. uncovered GPx7’s role in Barrett’s esophagus: reconstituting GPx7 in bile-salt–treated or TNF-α–stimulated esophageal cells inhibits p65 phosphorylation and cytokine/chemokine up-regulation, and clinical samples show inverse correlations between GPx7 levels and pro-inflammatory transcripts, implicating GPx7 loss in tumorigenesis [131]. Here, GPX7 is linked to esophageal adenocarcinoma.