Crack et al. showed that mice lacking GPx1 suffer larger infarcts after cerebral ischemia–reperfusion because elevated ROS drives serine-536 phosphorylation of NF-κB p65 and enhanced p50/p65 DNA binding—effects that a broad-spectrum NF-κB inhibitor rescues [128]. The gene discussed is NFKB1; the disease is Cerebral ischemia.