Although no direct assessment of the Wnt pathway levels was performed, the authors observed an accompanying increase in the levels of β-catenin and its downstream targets c-Myc, Cyclin D1, FoxA2 (Forkhead box A2), and MMP7 (matrix metalloproteinase 7), along with a decrease in Axin2, a Wnt pathway inhibitor, potentially suggesting a possible effect of GPx3 on the cancer progression-promoting Wnt/β-catenin signaling pathway [75]. The gene discussed is MMP7; the disease is cancer.