PRDX2 and neoplasm: PRX2 knockdown: ↑ ROS & apoptosis; ↓ proliferation, sphere-formation, migration, invasion, angiogenesis; no significant Wnt/Hedgehog/Notch inhibition. miR-122 silencing of PRX2: further ↑ ROS & apoptosis; strong suppression of Wnt/β-catenin, Hedgehog, and Notch pathways; abrogated CSC traits and in vivo tumor growth