GPX4 and melanoma: Also, exploring how redox agents like hyperforin induce ferroptosis by disrupting iron homeostasis and antioxidant defenses (GPx4, SLC7A11 (cystine/glutamate antiporter subunit), ferritin) and interact with melanoma pathways (HMOX1–BACH1 (BTB and CNC homology 1), MAPK, EMT markers) could advance treatment strategies [40].