For instance, Ecklonia cava extract [182], RU.521 [192], and Hirudin [193] collectively ameliorate mitochondrial dysfunction-induced hypertension or hypertensive cardiac injury by targeting multiple stages of the pathological cascade: inhibiting mtDNA oxidative damage, suppressing cGAS activation, and blocking NLRP3 inflammasome assembly, respectively. This evidence concerns the gene CGAS and hypertensive disorder.