NOX4 and ischemia: Short reperfusion (25 min ischemia/1 h reperfusion) in NOX4-overexpressing mice led to increased infarct size and impaired energetics [80] (Table 3), whereas longer reperfusion (30 min ischemia/3–7 days reperfusion) in a similar model improved cardiac function and promoted reparative M2 macrophage polarization [74] (Table 1).