Several studies have demonstrated that increased NOX4 expression and/or activity can play a protective role in heart diseases by promoting adaptive signaling pathways: these beneficial effects include enhancing cellular survival [24,25], stimulating angiogenesis [26,27,28], modulating autophagy [25] and fatty acid oxidation [29], facilitating stress resilience in cardiac cells and thereby contributing to improved cardiac function and limiting damage under certain pathological conditions. This evidence concerns the gene NOX4 and heart disorder.