NOX4 and aortic valve stenosis: Finally, Moreno et al. [57] suggested a potential role of NOX4 deficiency in adverse heart remodeling, as myocardial NOX4 levels were abnormally decreased in patients with severe aortic valve stenosis (consequent to pressure-overload), and correlated positively with parameters of LV systolic function, i.e., ejection fraction and fractional shortening, in these patients.