NOX4 and Myocardial fibrosis: In Sprague-Dawley rats with left anterior descending (LAD) coronary artery ligation, NOX4 adenoviral overexpression abrogated the beneficial effects of endostatin and Tanshinone IIA on myocardial ischemia (MI), and exacerbated LV systolic dysfunction and myocardial fibrosis [92,93] (Table 3).