In inflamed tissues, oxidized low-density lipoprotein (ox-LDL) accumulates and ligates the scavenger receptor LOX-1, amplifying reactive oxygen species, activating NF-κB/STAT3 signaling, and fostering an epithelial–mesenchymal transition phenotype—molecular programs linked to tumor growth, invasion, and therapy resistance [3,16]. This evidence concerns the gene NFKB1 and neoplasm.