Pre-clinical mouse models of DMD and muscle biopsies from DMD patients show deregulation of Bmal1, Cry1 and Cry2 in dystrophic muscles [99], which may result from disrupted dystrophin- RhoA-actin-SRF (serum response factor) signalling required for the molecular clock resetting [100]. This evidence concerns the gene DMD and Duchenne muscular dystrophy.