GPX4 and neoplasm: For instance, Zhang et al. designed folic acid-conjugated IONPs loaded with cisplatin and siRNA targeting GPX4 (FA/Pt-si-GPX4@IONPs), which significantly suppressed tumor growth in both U87MG and patient-derived xenograft models via synergistic ROS accumulation and ferroptosis induction, with negligible systemic toxicity [284].