In this study, after confirming the role of the Glo1/MG-H1 axis driven by the PTEN/PKM2/ERα pathway in promoting the aggressive phenotype of human PCa cells, we unrevealed a downstream mechanism involving RAGE, H2O2, and KRIT1 related to the Glo1/MG-H1 axis. This evidence concerns the gene ESR1 and posterior cortical atrophy.