Consistent with this central role, IL-10–centered tolerance reliably dampens tissue inflammation across diverse settings [47,48]: Pediococcus pentosaceus KF159 mitigated house-dust-mite–induced atopic dermatitis by boosting IL-10 and regulatory T cells (Tregs) induction [49], and helminth-derived metabolites imprinted DCs with tolerogenic functional, metabolic, and transcriptional signatures that attenuated experimental colitis [50]. The gene discussed is IL10; the disease is colitis.