However, Middleton et al. report that calcitriol (10−7 and 10−9 M) and its analog seocalcitol (10−9 M) increased CAT protein expression in canine bladder transitional cell carcinoma (cbTCC), with no effect on SOD2 or SOD1 protein expression [107]. Here, SOD1 is linked to bladder transitional cell carcinoma.