Figure 6 illustrates the integrated role of the NAD+ SIRT1 axis in cancer, highlighting its role in redox regulation, senescence evasion, and therapeutic vulnerability. Table 2 summarizes the representative SIRT1 inhibitors, their mechanisms of action, and their therapeutic effects, demonstrating how pharmacological disruption of this axis can sensitize tumors to oxidative stress and improve treatment responses. The gene discussed is SIRT1; the disease is cancer.