These pathways include the PI3K-Akt signaling pathway (hsa04151), lipid and atherosclerosis (hsa05417), the HIF-1 signaling pathway (hsa04066), EGFR tyrosine kinase inhibitor resistance (hsa01521), and the AGE-RAGE signaling pathway in diabetic complications (hsa04933) (Figure 6c). Here, PIK3CA is linked to atherosclerosis.