Integrated network pharmacology and molecular docking elucidate that the 26 potential hypoglycemic compounds in MLSG may exert anti-type 2 diabetes mellitus (T2DM) effects by synergistically regulating core targets (STAT3, AKT1, PIK3CA, EGFR, and MAPK1) and modulating the AGE-RAGE, PI3K-Akt, and HIF-1 other signaling pathways. Here, PIK3CB is linked to diabetes mellitus.