In conclusion, paclitaxel and cephalomannine combination treatment may lead to activation of phosphorylation and activation of p38, upregulation of p53 signaling, induction of mitochondrial dysfunction, promotion of Caspase activation, and cleavage of anti-apoptotic substrates such as PARP, ultimately resulting in the widespread apoptosis of tumor cells. This evidence concerns the gene TP53 and neoplasm.