ERBB2 and neoplasm: Furthermore, CAR-macrophages targeting VEGFR2, a vascular endothelial growth factor receptor in the TME [124], and HER2-CD147-CAR-macrophages targeting both the cancer antigen HER-2 and collagen fibers in the TME [125] may simultaneously improve the immune environment in the TME in addition to phagocytosing tumor cells.