CD8A and neoplasm: Nanoparticles prepared in this way could effectively target tumor cells and showed synergistic photothermal therapy, resulting in the release of whole-cell tumor antigens via photothermal-induced tumor necrosis, which enhanced antitumor immunotherapy for the primary tumor and metastatic tumor by activating CD8+ cytotoxic T cells and reducing regulatory Foxp3+ T cells [106].