Bin Y. et al. [96] identified ten NOTCH signalling pathway-related genes (SNW1, NOTCH3, ADAM17, MAML2, NUMBL, DTX2, DTX4, DTX3L, HES1, CIR1) and, based on their expression, classified bladder cancer into two subtypes C1 (upregulated ADAM17, DTX3L, MAML2, SNW1, NOTCH3, NUMBL) and C2. This evidence concerns the gene NUMBL and urinary bladder cancer.