NUMBL and urinary bladder carcinoma: Bin Y. et al. [96] identified ten NOTCH signalling pathway-related genes (SNW1, NOTCH3, ADAM17, MAML2, NUMBL, DTX2, DTX4, DTX3L, HES1, CIR1) and, based on their expression, classified bladder cancer into two subtypes C1 (upregulated ADAM17, DTX3L, MAML2, SNW1, NOTCH3, NUMBL) and C2.