Mechanistically, PARP10 could be involved in transcription and epigenomic regulation in AML, PARP14 promotes the proliferation of AML by excessively activating the NF-κB signaling pathway, further upregulating HIF-1α expression and thereby augmenting glycolytic flux in AML cells. The gene discussed is NFKB1; the disease is acute myeloid leukemia.