The results demonstrated that PARP3 knockdown impaired the phosphorylation protein level of PI3K p85 in AML cells, as well as both the total and phosphorylated protein levels of the key PI3K downstream effectors AKT and mTOR, whereas there were no significant differences in the protein levels of the PI3K catalytic subunits p110δ or p110γ. Here, MTOR is linked to acute myeloid leukemia.