A recent study of 41 iCCA patients, including HBV-positive cases, showed that HBV DNA integration is frequently observed in iCCA tumors and combined hepatocellular cholangiocarcinoma, with recurrent insertions identified near oncogenes such as telomerase reverse transcriptase (TERT), mesenchymal–epithelial transition factor, and ALKBH5 [128]. The gene discussed is ALKBH5; the disease is infantile convulsions and choreoathetosis.