SPP1 and non-small cell lung carcinoma: Other methylated genes with low evidence associated with EGFR-TKI resistance in NSCLC are programmed cell death ligand (PD-L1) [121], gamma-aminobutyric scid type B receptor subunit 2 (GABBR2) [122], secreted frizzled related protein 5 (SFRP5) [123], death-associated protein kinase (DAPK) [124,125], Klotho (KL) and S100 calcium binding protein P (S100P) [126], secreted phosphoprotein 1 (SPP1) and CD44 [127], RASSF1A and growth arrest and DNA damage-inducible protein GADD45 beta (GADD45β) [128], Bcl 2 like protein 11 (BIM) [129], and cyclin dependent kinase 14 (CDK14) [130].