CEN decreased MMP levels and suppressed tumor growth while inhibiting angiogenesis by downregulating cyclooxygenase-2 (COX-2), VEGF, CD31, and MAPK pathway proteins in both in vitro and in vivo models [100], highlighting how nanoencapsulation potentiates apoptotic and anti-angiogenic signaling. This evidence concerns the gene PTGS2 and neoplasm.