Osteosarcoma had 25 significant relationships, notably including IL-4/IL-1β (r2 = 0.58, p = 0.000048), IL-12 p40/IL-4 (r2 = 0.47, p = 0.0015), CXCL5/IL-27 (r2 = −0.48, p = 0.001), CXCL14/IL-15 (r2 = 0.66, p = 0.0000021). This evidence concerns the gene IL27 and osteosarcoma.