PKM and neoplasm: Given that key glycolytic enzymes such as HK2, PKM2, LDHA, and GLUT1 are well-established downstream targets transcriptionally activated by HIF-1α [25,26], and that previous studies have demonstrated that HIF-1α-mediated induction of glycolytic gene expression during hypoxic responses promotes metabolic reprogramming in tumor cells [27], we hypothesized that Curcumol’s inhibitory effect on glycolysis may be related to its regulation of the HIF-1α signaling axis.