However, genetic or functional loss of VHL leads to the accumulation of HIF-1α, which subsequently upregulates key glycolytic enzymes such as hexokinase-2 (HK2) and lactate dehydrogenase A (LDHA), promoting glucose uptake and lactate production, ultimately enhancing tumor proliferation and metastatic potential [12,13]. The gene discussed is HIF1A; the disease is neoplasm.