TFRC and glioblastoma: More recently, Flubendazole, from the benzimidazole class, was tested in the U251 and LN229 GBM cell lines, inducing cell death by ferroptosis accompanied by p53 and transferrin receptor (TFRC) upregulation, as well as solute carrier family 7 member 11 (SLC7A11) downregulation (Figure 1).